9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases.

摘要: Ependymomas are glial neoplasms whose clinical behavior is difficult to predict based on histology alone. Recently, a comparative genomic hybridization study identified frequent chromosome 9p and 13q losses in anaplastic ependymomas, suggesting that p16 RB alterations may be involved tumor progression. In order test this hypothesis further, 101 myxopapillary, conventional, ependymomas (51 spinal 50 intracranial tumors) were tested for deletions using fluorescence situ hybridization. Clinical follow-up, ranging from 2 198 months (median 46 months), was obtained 90 cases (91%). seen 22 of 92 (24%) 89 (25%) informative cases, respectively. Polysomies more the grade I II tumors, consistent with prior reports increased aneuploidy such cases. No significant genetic associations grade, recurrence, or death, do not play prominent role malignant progression as has been implicated other glioma subtypes.