The Role of 5-HT3 and Other Excitatory Receptors in Central Cardiorespiratory Responses to Hypoxia: Implications for Sudden Infant Death Syndrome
作者： Olga Dergacheva , Harriet Kamendi , Xin Wang , Ramon Manchon Pinol , Julie Frank
DOI: 10.1203/PDR.0B013E3181A16E9C
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摘要: Although brainstem serotonergic (5-HT) systems are involved in the protective responses to hypoxia, abnormalities of 5-HT function strongly implicated SIDS, and neurochemical mechanisms by which receptors influence cardiorespiratory hypoxia remains unclear. This study focuses on role excitatory neurotransmission, including 5-HT3 signaling, cardiac vagal neurons (CVNs) that dominate control heart rate. Excitatory synaptic inputs CVNs, located nucleus ambiguus (NA), were recorded simultaneously with respiratory activity vitro slices. During conditions CVNs blocked application NMDA AMPA/kainate glutamatergic receptor antagonists, whereas purinergic antagonists ondansetron pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid (PPADS), respectively, had no effect. However, during inhibited neurotransmission CVNs. In recovery from spontaneous respiratory-related events blockers, ondancetron These results demonstrate recruits a pathway activates maintain parasympathetic hypoxia. Exaggeration this could increase incidence bradycardia risk sudden infant death
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sci-hub.se 参考文章(45)
Hannah C. Kinney, James J. Filiano, W. F. White, Medullary serotonergic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single dataset. Journal of Neuropathology and Experimental Neurology. ,vol. 60, pp. 228- 247 ,(2001) , 10.1093/JNEN/60.3.228
Alix D, Sizun J, Caroff J, Girin E, Cann-Moisan C, Barthelemy L, Neurotransmission and sudden infant death. Study of cerebrospinal fluid Comptes Rendus De L Academie Des Sciences Serie Iii-sciences De La Vie-life Sciences. ,vol. 314, pp. 451- 454 ,(1992)
Robert G. Meny, Dorothy H. Kelly, John L. Carroll, Mary Terese Carbone, Cardiorespiratory Recordings From Infants Dying Suddenly And Unexpectedly at Home Pediatrics. ,vol. 93, pp. 44- 49 ,(1994)
E. W. Taylor, P. J. Butler, Nervous control of heart rate: activity in the cardiac vagus of the dogfish. Journal of Applied Physiology. ,vol. 53, pp. 1330- 1335 ,(1982) , 10.1152/JAPPL.1982.53.6.1330
C. Cann-Moisan, E. Girin, J.D. Giroux, P. Le Bras, J. Caroff, Changes in cerebrospinal fluid monoamine metabolites, tryptophan, and gamma-aminobutyric acid during the 1st year of life in normal infants. comparison with victims of sudden infant death syndrome. Neonatology. ,vol. 75, pp. 152- 159 ,(1999) , 10.1159/000014091
X. W. Fu, C. A. Nurse, V. Wong, E. Cutz, Hypoxia‐induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit The Journal of Physiology. ,vol. 539, pp. 503- 510 ,(2002) , 10.1113/JPHYSIOL.2001.013071
Yun Wang, Andrew G. Ramage, David Jordan, Mediation by 5-HT3 receptors of an excitatory effect of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study. British Journal of Pharmacology. ,vol. 118, pp. 1697- 1704 ,(1996) , 10.1111/J.1476-5381.1996.TB15594.X
J.N Schuen, O.S Bamford, J.L Carroll, The cardiorespiratory response to anoxia: normal development and the effect of nicotine Respiration Physiology. ,vol. 109, pp. 231- 239 ,(1997) , 10.1016/S0034-5687(97)00052-2
Daniel M Leal, João Carlos Callera, Leni G.H Bonagamba, Anne Nosjean, Raul Laguzzi, Benedito H Machado, Microinjection of a 5-HT3 receptor agonist into the NTS of awake rats inhibits the bradycardic response to activation of the von Bezold-Jarisch reflex. Brain Research Bulletin. ,vol. 54, pp. 7- 11 ,(2001) , 10.1016/S0361-9230(00)00408-1
C. Evans, J. Wang, R. Neff, D. Mendelowitz, Hypoxia recruits a respiratory-related excitatory pathway to brainstem premotor cardiac vagal neurons in animals exposed to prenatal nicotine. Neuroscience. ,vol. 133, pp. 1073- 1079 ,(2005) , 10.1016/J.NEUROSCIENCE.2005.03.053