Opioid System and Alzheimer's Disease

摘要: The opioid system may be involved in the pathogenesis of AD, including cognitive impairment, hyperphosphorylated tau, Ab production, and neuroin- flammation. Opioid receptors influence regulation neurotransmitters such as acetylcholine, norepinephrine, GABA, glutamate, serotonin which have been impli- cated AD. has a close relation with generation since dysfunction retards endocytosis degradation BACE1 c-secretase upregulates c-secretase, subsequently, production Ab. Con- versely, activation increases endo- cytosis downregulates limiting (opioid peptides) contribute to hyperphosphorylation tau neuroinflammation, accounts for degeneration cholinergic neurons impairment. Thus, is potentially related AD pathology very attractive drug target novel pharmaco- therapies