MACPF/CDC proteins in development: Insights from Drosophila torso-like

摘要: The Membrane Attack Complex Perforin-like/Cholesterol-Dependent Cytolysin (MACPF) superfamily is an ancient and biologically diverse group of proteins that are best known for pore-forming roles in mammalian immunity bacterial pathogenesis. Intriguingly, however, some eukaryotic which contain the MACPF domain defines this family do not act attack or defence, instead have distinct developmental functions. It remains unclear whether these function via pore formation a different mechanism action. Of these, by far characterised Torso-like (Tsl), only member has been identified fruit fly, Drosophila melanogaster. While it long to role embryonic patterning, recent studies shown Tsl fact multiple development. As such, presents excellent opportunity investigate how functions context. Here, we review what about other insects, discuss potential molecular thus may function.