Disodium cromoglycate prevents ileum hyperreactivity to histamine in Toxocara canis-infected guinea pigs.

作者: Anderson de Sá-Nunes , Alexandre Pinto Corrado , Marcelo Dias Baruffi , Lúcia Helena Faccioli

DOI: 10.1016/S1043-6618(03)00208-1

关键词:

摘要: Abstract The aim of this study was to investigate whether Toxocara canis infection in guinea pigs provokes changes ileum responsiveness histamine. Ileum segments from control and T. -infected groups were placed at isometric conditions submitted various doses No observed between controls days 3, 6 12 after infection. However, 18 24 infection, there a significant increase histamine group. Pre-incubation with 1 mg ml −1 disodium cromoglycate (DSCG) prevented the increased did not affect contractility non-infected animals. These results indicate that develop intestinal DSCG prevents alterations smooth-muscle contractility.

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