Model systems: Studying molecular recognition using bacterial n-hybrid systems

摘要: Abstract Since the first description of yeast two-hybrid system, related genetic assays for protein–protein interactions have become popular and powerful tools structure–function analysis on scale individual proteins or whole proteomes. After a somewhat surprising lag, similar systems recently been described use in bacterial hosts. n-hybrid modifications original system used to examine with DNA, RNA small molecules, other improved throughput genomic applications. Bacterial are being designed array uses. Will be as systems? Only time will tell.