Special Section:Future Trendsin Vaccination: Advances in cancer vaccine development
作者： Dorothee Herlyn , Brigitte Birebent
DOI: 10.3109/07853899909019264
关键词:
摘要: Traditionally, cancer vaccines have used whole tumour cells administered in adjuvant or infected with viruses to increase the immunogenicity of cells. With identification tumour-associated and tumour-specific antigens (TAA, TSA), antigen epitope-specific been designed. Compared cell vaccines, epitope are more specific easier produce large quantities but may display lower lead vivo selection epitope-negative escape variant The optimal vaccine will elicit both humoral cellular immunity patients as parameters positively correlated induction beneficial clinical responses. choice adjuvant, costimulation delivery mode greatly determines outcome vaccinations favour T-cell responses T helper (Th)1, Th2, Thl Th2 types. Animal models TAA must take into account normal tissue expres...
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