Randomized, Multinational, Phase III Study of Docetaxel Plus Platinum Combinations Versus Vinorelbine Plus Cisplatin for Advanced Non–Small-Cell Lung Cancer: The TAX 326 Study Group
作者： Frank Fossella , Jose R. Pereira , Joachim von Pawel , Anna Pluzanska , Vera Gorbounova
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摘要: Purpose: To investigate whether docetaxel plus platinum regimens improve survival and affect quality of life (QoL) in advanced non–small-cell lung cancer (NSCLC) compared with vinorelbine cisplatin as first-line chemotherapy. Patients Methods: (n = 1,218) stage IIIB to IV NSCLC were randomly assigned receive 75 mg/m2 every 3 weeks (DC); carboplatin area under the curve 6 mg/mL • min (DCb); or 25 mg/m2/wk 100 4 (VC). Results: treated DC had a median 11.3 v 10.1 months for VC-treated patients (P .044; hazard ratio, 1.183 [97.2% confidence interval, 0.989 1.416]). The 2-year rate was 21% DC-treated 14% patients. Overall response 31.6% 24.5% .029). Median (9.4 9.9 [for VC]; P .657; 1.048 [97.2 confiden...
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