The importance of microRNAs in the stroma-breast cancer cell interplay.

摘要: Breast cancer is one of the most diagnosed cancers in women. Despite outstanding progress over past few years, breast remains second leading cause cancer-related death among This fact emphasizes need for im- proved diagnostic and prognostic markers, as well improved understanding environment, including crosstalk between epithelial stromal cells. The tumor microenvironment paramount progression dissemination. Accumulating evidence indicates that epigenetic phenomena such microRNAs are extremely important homeostasis. Through molecular mechanisms involved microenvironment-mediated promotion growth metastasis, novel targets therapeutic intervention or early diagnosis may be identified.