Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.
作者： Hongdo Do , Benjamin Solomon , Paul L Mitchell , Stephen B Fox , Alexander Dobrovic
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摘要: Background A recurrent somatic mutation, E17K, in the pleckstrin homology domain of AKT1 gene, has been recently described breast, colorectal, and ovarian cancers. is a pivotal mediator signalling pathways involved cell survival, proliferation growth. The E17K mutation stimulates downstream exhibits transforming activity vitro vivo.
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