Compositions and methods for identifying and testing TGF-β pathway agonists and antagonists
作者： Kirby Johnson , Allen Laughon , Jaeseob Kim
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摘要: The invention provides compositions and methods of identifying testing TGF-β pathway agonists antagonists, in particular comprising Mothers against DPP (MAD) proteins related Smad polypeptides which exhibit sequence-specific DNA-binding activity. also a novel DNA sequence (SEQ ID NO:19); NO:20); NO:21) that is bound with high affinity by Drosophila MAD protein. This protein useful for compounds will enhance or interfere protein-DNA binding.
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