Epidemiology of Clostridium difficile in Germany based on a single center long-term surveillance and German-wide genotyping of recent isolates provided to the advisory laboratory for diagnostic reasons.

摘要: Epidemiology of Clostridium difficile is characterized by worldwide increase C. infections (CDI) and the emergence new epidemic outbreak strains with capacity for global spreading. Long-term local surveillance at University Saarland Medical Center between 2000 2013 shows that incidence rate laboratory-confirmed CDI was influenced epidemiology as well testing strategies. Since 2008, molecular typing regularly performed symptomatic hospitalized patients surface-layer protein A sequence (slpAST), which an established highly standardized technique genotyping difficile. The results were assigned to known ribotypes better comparison international data. It could be demonstrated distribution genotypes different age groups. Older predominantly infected ribotype 001 027, whereas 027 not detected in pediatric population. Molecular German isolates sent advisory laboratory 2011 revealed present high percentages most regions except very North. In conclusion, optimized all diarrhea should generally implemented avoid under-diagnosis infection. Ribotype prevalent Germany, but its are restricted older patients, while absent children. suspected hospital outbreaks severe or recurrent disease may help understand virulence spreading