The effect of a polynutrient supplement on fatigue and physical activity of patients with chronic fatigue syndrome: a double-blind randomized controlled trial

摘要: Summary Background: The efficacy of dietary supplements in chronic fatigue syndrome (CFS) is uncertain, with conflicting evidence. Aim: To assess the effect a polynutrient supplement on and physical activity patients CFS. Design: Prospective randomized placebo-controlled, double-blind trial. Methods: Fifty-three (16 males, 37 females) fulfilling CDC criteria entry were score Checklist Individual Strength subscale severity (CIS fatigue) 040 weighted sum 0750 for eight subscales Sickness Impact Profile (SIP8) no use nutritional 4 weeks prior to entry. exclusion pregnancy lactose intolerance. intervention—a containing several vitamins, minerals (co)enzymes, or placebo, twice daily 10 weeks—was preceded by 2 baseline measurements. Outcome measurements took place week 9 intervention. Five participants dropped out (4 supplement, 1 placebo). main outcome measures CIS score, number symptoms SIP8 score. Efficacy analyses performed an intention-to-treat basis. Results: No significant differences found between placebo treated group any measures: q2.16 (95%CI 4.3 q4.39, p =0.984); q0.42 0.61 q1.46, p= 0.417); q182 165 q529, 0.297). patient reported full recovery. Discussion: findings do not support broad-spectrum treating CFS-related symptoms.