DNA methylation and cancer.
作者： Richard L. Momparler , Veronica Bovenzi
DOI: 10.1002/(SICI)1097-4652(200005)183:2<145::AID-JCP1>3.0.CO;2-V
关键词:
摘要: The methylation of DNA is an epigenetic modification that can play important role in the control gene expression mammalian cells. enzyme involved this process methyltransferase, which catalyzes transfer a methyl group from S-adenosyl-methionine to cytosine residues form 5-methylcytosine, modified base found mostly at CpG sites genome. presence methylated islands promoter region genes suppress their expression. This may be due 5-methylcytosine apparently interferes with binding transcription factors or other DNA-binding proteins block transcription. In different types tumors, aberrant accidental has been observed for many cancer-related resulting silencing How hypermethylation takes place not known. include tumor suppressor genes, metastasis and angiogenesis, repair suggesting epigenetics plays tumorigenesis. potent specific inhibitor methylation, 5-aza-2'-deoxycytidine (5-AZA-CdR) demonstrated reactivate most these "malignancy" human cell lines. These interesting targets chemotherapy inhibitors patients cancer help clarify importance mechanism
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