Cancer: The enemy of my enemy is my friend

摘要: Reactive oxygen species have been viewed as stress-inducing molecules that promote cancer initiation. But new evidence indicates oxidative stress can be beneficial — inhibiting the spread of a to other sites. See Article p.186 Although solid cells such melanoma readily enter circulation system, they are not very efficient at forming metastases sites away from original tumour. Sean Morrison and colleagues show human grown in mice experience high levels bloodstream, few metastasizing survive form tumours. The rare do successfully metastasize undergo metabolic changes increase their capacity withstand this stress. Antioxidant treatments metastasis by cells, while antioxidant pathways has opposite effect.