HER-2 gene amplification in Paget disease of the nipple and extramammary site: a chromogenic in situ hybridization study.

摘要: Patients with human epidermal growth factor receptor 2 (HER-2) overexpressing breast carcinomas have a more aggressive clinical behavior and their tumors are often hormone negative. However, the recently introduced anti-HER-2 antibody trastuzumab has been proven to improve survival controls disease in significant proportion of these patients. Therefore, analysis HER-2 patients cancer become an important routine test select those who may benefit from gene-based targeted therapy (herceptin). There is good correlation between HER-2/neu protein overexpression gene amplification cancer. inconsistent results reported rate other malignant neoplasms. Furthermore, only rare studies investigated status tumors. We several cases Paget nipple vulva by using chromogenic situ hybridization assay immunohistochemistry. find that majority demonstrate amplification, whereas most extramammary lack amplification. In addition, our show nipple, but we were unable confirm this vulva.