Early Target Genes of IL-12 and STAT4 Signaling in Th Cells
作者： Riikka J. Lund , Zhi Chen , Joonas Scheinin , Riitta Lahesmaa
DOI: 10.4049/JIMMUNOL.172.11.6775
关键词:
摘要: IL-12 signaling through STAT4 is essential for induction of optimal levels IFN-gamma production and commitment Th1 cells. The molecular mechanism that controls how induces differentiation poorly described. To identify the early target genes signaling, oligonucleotide arrays were used to compare gene expression profiles wild-type STAT4-knockout murine Th cells during differentiation. According results, 20 regulated in an IL-12- STAT4-dependent manner. Importantly, Ifngamma was clearly first induced by a Most other defects seen after 48 h polarization. In addition mediated STAT4, STAT4-independent number observed immediately response induction. This at least part driven independently STAT4. exogenous into cell cultures restored defect further demonstrating critical role
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