Effect of administration route on the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles.

摘要: The absorption and lymphatic delivery of a new immunosuppressive drug, cyclosporin A (CsA), with the aid lipid surfactant mixed micelles (MM) system using different administration routes were studied in thoracic duct cannulated rat model at dose level 7 mg/kg. rectal or intraperitoneal (i.p.) CsA indicated small amount plasma lymph for 6 h. As oral routes, intrastomach (i.s.) intraduodenal (i.d.) performed high levels obtained. i.s. resulted highest lymph, 16 μg/ml, about twenty times higher than i.p. administration. These results strongly support usefulness an dosage form selective clinical therapy by means system.