Enhancement of hippocampal acetylcholine release by the neurosteroid dehydroepiandrosterone sulfate: an in vivo microdialysis study.
作者： Michael E Rhodes , Pui-Kai Li , James F Flood , David A Johnson
DOI: 10.1016/0006-8993(96)00751-2
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摘要: The effect of dehydroepiandrosterone sulfate (DHEAS) administered i.p. on the release acetylcholine (ACh) from hippocampus anesthetized rats was examined using in vivo microdialysis. DHEAS significantly increased ACh above pre-treatment levels for all doses tested. administration 100 mg/kg enhanced greater than 4-fold when compared to saline-treated group 80 min following drug administration. This study is first demonstrate that neurosteroid DHEAS, a negative allosteric modulator GABAA receptor, can enhance neurons hippocampus.
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