Targeting adenosine A2A receptor antagonism for treatment of cancer

作者: Miles Congreve , Giles A. Brown , Alexandra Borodovsky , Michelle L. Lamb

DOI: 10.1080/17460441.2018.1534825

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摘要: Introduction: Adenosine A2A Receptor (A2AR) antagonists are an emerging class of agents that treat cancers, both as a monotherapy and in combination with other therapeutic agents. Several studies s...

参考文章(84)
Fiona Thomson, Parkinson's Disease Neuron. ,vol. 39, pp. 889- 909 ,(2003) , 10.1016/S0896-6273(03)00568-3
Robert M. Cooke, Alastair J.H. Brown, Fiona H. Marshall, Jonathan S. Mason, Structures of G protein-coupled receptors reveal new opportunities for drug discovery. Drug Discovery Today. ,vol. 20, pp. 1355- 1364 ,(2015) , 10.1016/J.DRUDIS.2015.08.003
Miles Congreve, Rebecca L. Rich, David G. Myszka, Francis Figaroa, Gregg Siegal, Fiona H. Marshall, Fragment screening of stabilized G-protein-coupled receptors using biophysical methods. Methods in Enzymology. ,vol. 493, pp. 115- 136 ,(2011) , 10.1016/B978-0-12-381274-2.00005-4
Jonathan Blay, David W. Hoskin, Thomas D. White, The Extracellular Fluid of Solid Carcinomas Contains Immunosuppressive Concentrations of Adenosine Cancer Research. ,vol. 57, pp. 2602- 2605 ,(1997)
Delia Preti, Pier Giovanni Baraldi, Allan R Moorman, Pier Andrea Borea, Katia Varani, None, History and Perspectives of A2A Adenosine Receptor Antagonists as Potential Therapeutic Agents Medicinal Research Reviews. ,vol. 35, pp. 790- 848 ,(2015) , 10.1002/MED.21344
Robert A. Hodgson, Paul J. Bedard, Geoffrey B. Varty, Tatiana M. Kazdoba, Therese Di Paolo, Michael E. Grzelak, Annamarie J. Pond, Abdallah HadjTahar, Nancy Belanger, Laurent Gregoire, Aurelie Dare, Bernard R. Neustadt, Andrew W. Stamford, John C. Hunter, Preladenant, a selective A2A receptor antagonist, is active in primate models of movement disorders Experimental Neurology. ,vol. 225, pp. 384- 390 ,(2010) , 10.1016/J.EXPNEUROL.2010.07.011
Krzysztof Rataj, Jagna Witek, Stefan Mordalski, Tomasz Kosciolek, Andrzej J. Bojarski, Impact of Template Choice on Homology Model Efficiency in Virtual Screening Journal of Chemical Information and Modeling. ,vol. 54, pp. 1661- 1668 ,(2014) , 10.1021/CI500001F
Xiao-Xia Lu, Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma World Journal of Gastroenterology. ,vol. 19, pp. 1912- 1918 ,(2013) , 10.3748/WJG.V19.I12.1912
Rebecca L. Rich, James Errey, Fiona Marshall, David G. Myszka, Biacore analysis with stabilized G-protein-coupled receptors. Analytical Biochemistry. ,vol. 409, pp. 267- 272 ,(2011) , 10.1016/J.AB.2010.10.008
Paul. A. Beavis, John Stagg, Phillip K. Darcy, Mark J. Smyth, CD73: a potent suppressor of antitumor immune responses Trends in Immunology. ,vol. 33, pp. 231- 237 ,(2012) , 10.1016/J.IT.2012.02.009