Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis

摘要: Abstract In allergen challenged animal models, eosinophils localize to airway nerves leading vagally-mediated hyperreactivity. We hypothesized that in allergic rhinitis recruited nasal resulted neural Patients with persistent (n = 12), seasonal (n = 7) and controls (n = 10) were studied. Inferior turbinate biopsies obtained before, 8 48 h after challenge. Eight hours challenge localized both groups; this was sustained through 48 h. Bradykinin challenge, secretion collection on the contralateral side, performed demonstrate nerve reflexes. Twenty four hours bradykinin induced a significant increase secretions, indicating Histological studies showed expressed vascular cell adhesion molecule-1 (VCAM-1) chemokine (C-C motif) ligand 26 (CCL-26). Hence, are retained at so may be mechanism for