KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes
作者： Titli Nargis , Krishna Kumar , Amrit Raj Ghosh , Amit Sharma , Dipayan Rudra
DOI: 10.1016/J.MOLMET.2017.09.004
关键词:
摘要: Objective Increasing plasma levels and activity of dipeptidyl peptidase-4 (DPP4 or CD26) are associated with rapid progression metabolic syndrome to overt type 2 diabetes mellitus (T2DM). While DPP4 inhibitors increasingly used as anti-hyperglycemic agents, the reason for increase in T2DM patients remains elusive.
eurekamag.com
core.ac.uk 参考文章(52)
W Stoffel, K Hofmann, Tmbase-A database of membrane spanning protein segments Biol. Chem. Hoppe-Seyler. ,vol. 374, pp. 166- 166 ,(1993)
Fernando Zapata-Gonzalez, Teresa Auguet, Gemma Aragonès, Esther Guiu-Jurado, Alba Berlanga, Salomé Martinez, Andreu Martí, Fátima Sabench, Mercé Hernandez, Carmen Aguilar, Joan Sirvent, Rosa Jorba, Daniel Del Castillo, Cristóbal Richart, Interleukin-17A Gene Expression in Morbidly Obese Women International Journal of Molecular Sciences. ,vol. 16, pp. 17469- 17481 ,(2015) , 10.3390/IJMS160817469
Yasushi Kirino, Masako Sei, Kazuyoshi Kawazoe, Kazuo Minakuchi, Youichi Sato, Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people. Endocrine Journal. ,vol. 59, pp. 949- 953 ,(2012) , 10.1507/ENDOCRJ.EJ12-0158
J. C. Pickup, Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. ,vol. 27, pp. 813- 823 ,(2004) , 10.2337/DIACARE.27.3.813
Felix Kreier, Yolanda S. Kap, Thomas C. Mettenleiter, Caroline van Heijningen, Jan van der Vliet, Andries Kalsbeek, Hans P. Sauerwein, Eric Fliers, Johannes A. Romijn, Ruud M. Buijs, Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology. ,vol. 147, pp. 1140- 1147 ,(2006) , 10.1210/EN.2005-0667
Zhendi Wang, Christina Grigo, Julia Steinbeck, Stephan von Hörsten, Kerstin Amann, Christoph Daniel, Soluble DPP4 originates in part from bone marrow cells and not from the kidney. Peptides. ,vol. 57, pp. 109- 117 ,(2014) , 10.1016/J.PEPTIDES.2014.05.006
Ioannis Prassas, Azza Eissa, Gennadiy Poda, Eleftherios P. Diamandis, Unleashing the therapeutic potential of human kallikrein-related serine proteases Nature Reviews Drug Discovery. ,vol. 14, pp. 183- 202 ,(2015) , 10.1038/NRD4534
Daniel J. Drucker, Steven I. Sherman, Richard M. Bergenstal, John B. Buse, The Safety of Incretin-Based Therapies—Review of the Scientific Evidence The Journal of Clinical Endocrinology and Metabolism. ,vol. 96, pp. 2027- 2031 ,(2011) , 10.1210/JC.2011-0599
Magis Mandapathil, Benedict Hilldorfer, Miroslaw J Szczepanski, Malgorzata Czystowska, Marta Szajnik, Jin Ren, Stephan Lang, Edwin K Jackson, Elieser Gorelik, Theresa L Whiteside, None, Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+ Regulatory T Cells Journal of Biological Chemistry. ,vol. 285, pp. 7176- 7186 ,(2010) , 10.1074/JBC.M109.047423
Markus Feuerer, Laura Herrero, Daniela Cipolletta, Afia Naaz, Jamie Wong, Ali Nayer, Jongsoon Lee, Allison B Goldfine, Christophe Benoist, Steven Shoelson, Diane Mathis, Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters Nature Medicine. ,vol. 15, pp. 930- 939 ,(2009) , 10.1038/NM.2002