Transketolase and fructose-1,6-bis-phosphate aldolase, complementary tools for access to new ulosonic acid analogues
作者： Dominique Crestia , Colette Demuynck , Jean Bolte
DOI: 10.1016/J.TET.2003.12.069
关键词:
摘要: Abstract A new approach to the synthesis of ulosonic acids KDO and DAH is described. The key step C 5 –C 6 bond formation catalysed by fructose-1,6-bisphosphate aldolase (for KDO) or transketolase DAH) using substituted acrylonitrile α-hydroxyaldehyde. All asymmetric carbon configurations are determined in an enzymatic means deshydrogenase lipase. This strategy, a non-metabolism pathway, allows access novel precursors KDO, analogues.
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