Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition
作者： Gerben C.M. Zondag , Eva E. Evers , Jean P. ten Klooster , Lennert Janssen , Rob A. van der Kammen
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摘要: Proteins of the Rho family regulate cytoskeletal rearrangements in response to receptor stimulation and are involved in the establishment and maintenance of epithelial cell morphology. …
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Frits Michiels, Rob A. Van Der Kammen, Lennert Janssen, Garry Nolan, John G. Collard, Expression of Rho GTPases using retroviral vectors. Methods in Enzymology. ,vol. 325, pp. 295- 302 ,(2000) , 10.1016/S0076-6879(00)25451-7
Giorgio Scita, Johan Nordstrom, Roberta Carbone, Pierluigi Tenca, Giuseppina Giardina, Silvio Gutkind, Mattias Bjarnegård, Christer Betsholtz, Pier Paolo Di Fiore, EPS8 and E3B1 transduce signals from Ras to Rac Nature. ,vol. 401, pp. 290- 293 ,(1999) , 10.1038/45822
Frank N. van Leeuwen, Sanne van Delft, Hendrie E. Kain, Rob A. van der Kammen, John G. Collard, Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading Nature Cell Biology. ,vol. 1, pp. 242- 248 ,(1999) , 10.1038/12068
Michael F. Olson, Hugh F. Paterson, Christopher J. Marshall, Signals from Ras and Rho GTPases interact to regulate expression of p21 Waf1/Cip1 Nature. ,vol. 394, pp. 295- 299 ,(1998) , 10.1038/28425
Patricia J. Keely, John K. Westwick, Ian P. Whitehead, Channing J. Der, Leslie V. Parise, Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K Nature. ,vol. 390, pp. 632- 636 ,(1997) , 10.1038/37656
Crislyn D’Souza-Schorey, Benjamin Boettner, Linda Van Aelst, Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes Molecular and Cellular Biology. ,vol. 18, pp. 3936- 3946 ,(1998) , 10.1128/MCB.18.7.3936
J Behrens, M M Mareel, F M Van Roy, W Birchmeier, Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. Journal of Cell Biology. ,vol. 108, pp. 2435- 2447 ,(1989) , 10.1083/JCB.108.6.2435
D Bar-Sagi, J. Feramisco, Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins Science. ,vol. 233, pp. 1061- 1068 ,(1986) , 10.1126/SCIENCE.3090687
M S Kinch, G J Clark, C J Der, K Burridge, Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia Journal of Cell Biology. ,vol. 130, pp. 461- 471 ,(1995) , 10.1083/JCB.130.2.461
Todd M. Kinsella, Garry P. Nolan, Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus Human Gene Therapy. ,vol. 7, pp. 1405- 1413 ,(1996) , 10.1089/HUM.1996.7.12-1405