Natural history of low grade dysplasia in patients with primary sclerosing cholangitis and ulcerative colitis

摘要: Abstract Background and Aim Patients with ulcerative colitis (UC) primary sclerosing cholangitis (PSC) are at increased risk of colon cancer. The aim this study was to determine the natural history LGD its progression high grade dysplasia (HGD)/colorectal cancer (CRC) in PSC–UC patients. Methods Ten patients who underwent surveillance colonoscopy from 1996 2011 were evaluated. Raised defined as a discrete raised lesion located an area involved by either quiescent or active that endoscopically resected, while flat absence documentation lesion. Results Of 10 LGD, 3 (30%) progressed HGD over mean follow-up 13±11months. Three had initial 7 LGD. location proximal all However distal morphology. incidence rate for detection HGD/CRC 9.4 cases per 100 person years risk. morphology 17.8 occurred more frequently within first year (23.5 patient follow-up). Conclusions One-third PSC–UC. Most progress diagnosis supporting early colectomy