Evaluation of antidiarrheal activity of ethanolic extract of Holarrhena antidysenterica seeds in rats.
作者： Dushyant Kumar Sharma , Vinod Kumar Gupta , Surendra Kumar , Vivek Joshi , Ravi Shankar Kumar Mandal
DOI: 10.14202/VETWORLD.2015.1392-1395
关键词:
摘要: Aim: The present study was conducted to evaluate the antidiarrheal effect of ethanolic extract Holarrhena antidysenterica (Family - Apocynaceae) seeds against induced diarrhea in Wistar albino rats. Materials and Methods: evaluated for castor oil Escherichia coli diarrhea. Extract given at 100, 200, 400 mg/kg body wt. orally both protocols. Standard Loperamide used 5 protocol, while standard antibiotic Gentamicin 8 intraperitoneally E. In percentage inhibition defecation calculated each group, whereas change fecal consistency, weight recorded individual rat 3 days. Results: severity reduced significantly (p<0.05) with H. 200 which showed equivalent effectiveness like that treated groups. Similarly mean higher positive control, no significant variation observed negative group wt., respectively. Conclusion: concluded effectively controlled decreased clinical signs
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