Anti-parasitic effects of Leptomycin B isolated from Streptomyces sp. CJK17 on marine fish ciliate Cryptocaryon irritans.
作者： Fei Yin , Peng Sun , Baojun Tang , Hui Gong , Qiaozhen Ke
DOI: 10.1016/J.VETPAR.2015.12.034
关键词:
摘要: The present study was conducted aiming to evaluate the in vitro and vivo anti-parasitic efficacy of an isolated compound against ciliate Cryptocaryon irritans. previously from fermentation products Streptomyces sp. CJK17 designated as SFrD. Toxicity SFrD fish hosts (Larimichthys crocea) also tested its chemical structure elucidated. obtained results showed that has potent with 10 min-, 1 h-, 2 3 h- 4 h-LC50 (95% Confidence Intervals) 6.8 (6.5-7.1), 3.9 (2.8-5.0), 3.3 (2.6-4.0), 2.7 (2.3-3.1) 2.5 (2.2-2.8) mg L(-1) theronts C. irritans 6h-LC50 CI) 3.0 (2.8-3.2) tomonts, respectively. Exposure remarkably reduced mortality infected Irritans, 100% control group 61.7% 38.3% groups 3.1 6.3 L(-1), In test exposing 40 for 24h, no visible effects were observed affecting normal behavior or any macroscopic changes. By spectrum analysis (EI-MS, (1)H NMR (13)C NMR), identified Leptomycin B. This firstly demonstrated B ciliates cultured marine fish.
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