Measuring the clinical response. What does it mean

摘要: The clinical response to treatment is an important indicator of the therapeutic effect anticancer agents. Its value and interpretation has be carefully considered within context that it used. In daily practice, assessment combined with other indicators patient's condition contribute decision-making process. trials, widely used identify quantify anti-tumour activity new this context, evaluation conducted on basis strict predefined criteria such as World Health Organization (WHO) or Response Evaluation Criteria Solid Tumors (RECIST) criteria. RECIST have recently been proposed offer a detailed guidance perform evaluation. Clinical also efficacy in combination indicators. surrogate survival benefit remains unclear most instances can hardly established framework single randomised trial. With development agents behave differently cytotoxics, will integrate concepts disease stabilisation time progression. Over next decade, oncologists able assess biological before response, lot work energy dedicated predictive and, possibly, prognostic regard well more definitive measures benefit.