Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers
作者： Daniel Hagerstrand , Alexander Tong , Steven E. Schumacher , Nina Ilic , Rhine R. Shen
DOI: 10.1158/2159-8290.CD-12-0592
关键词:
摘要: 3q26 is frequently amplified in several cancer types with a common region containing 20 genes. To identify driver genes this region, we interrogated the function of each these by loss- and gain-of-function genetic screens. Specifically, found that TLOC1 (SEC62) was selectively required for proliferation cell lines amplification. Increased expression induced anchorage independent growth second gene, SKIL (SNON), facilitated invasion immortalized human mammary epithelial cells. Expression both subcutaneous tumor growth. Proteomic studies demonstrated binds to DDX3X, which essential TLOC1-induced transformation affected protein translation. through up-regulation SLUG (SNAI2) expression. Together, as at more broadly suggest cooperating may be co-amplified other regions somatic copy number gain.
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