Regional difference of reactive astrogliosis following traumatic brain injury revealed by hGFAP-GFP transgenic mice.
作者： Woon Ryoung Kim , Joo Yeon Kim , Younghye Moon , Hyun Jung Kim , Hyun Kim
DOI: 10.1016/J.NEULET.2012.02.023
关键词:
摘要: Reactive astrocytes greatly influence the wound healing and neuronal regeneration processes following brain injury. However, origin fate of reactive appear to be different depending on type, severity duration Using cryogenic traumatic injury model, here we comprehensively addressed regional differences in injured cortex. In proximal region site, NG2-expressing cytoplasmic Olig2-labeled cells were densely localized 3 days after Next this layer, most did not express NG2 but exhibited radial glia-like shape with elongated processes. Accordingly, they expressed progenitor or glial markers, such as vimentin, lipid binding protein (BLBP) green fluorescent (GFP) under control human GFAP (hGFAP) promoter. only few fibrillary acidic (GFAP) expressing found layer. Distal strongly hypertonic morphology. At day 15 injury, all layers other marker expressions disappeared, indicating termination astrogliosis. Taken together, our data suggest that astrogliosis occurs a regionally segregated manner early phase
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sci-hub.se 参考文章(29)
Haitham Salman, Pritam Ghosh, Steven G. Kernie, Subventricular zone neural stem cells remodel the brain following traumatic injury in adult mice. Journal of Neurotrauma. ,vol. 21, pp. 283- 292 ,(2004) , 10.1089/089771504322972077
HD Soares, RR Hicks, D Smith, TK McIntosh, Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury The Journal of Neuroscience. ,vol. 15, pp. 8223- 8233 ,(1995) , 10.1523/JNEUROSCI.15-12-08223.1995
Woon Ryoung Kim, Sung Kun Chun, Tae Woo Kim, Hyun Kim, Katsuhiko Ono, Hirohide Takebayashi, Kazuhiro Ikenaka, Ronald W Oppenheim, Woong Sun, None, Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain. European Journal of Neuroscience. ,vol. 33, pp. 599- 611 ,(2011) , 10.1111/J.1460-9568.2010.07557.X
Christiane Simon, Magdalena Götz, Leda Dimou, Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury. Glia. ,vol. 59, pp. 869- 881 ,(2011) , 10.1002/GLIA.21156
S.K. Malhotra, M. Svensson, H. Aldskogius, R. Bhatnagar, G.D. Das, T.K. Shnitka, Diversity among reactive astrocytes: Proximal reactive astrocytes in lacerated spinal cord preferentially react with monoclonal antibody J1–31 Brain Research Bulletin. ,vol. 30, pp. 395- 404 ,(1993) , 10.1016/0361-9230(93)90271-C
W. T. Norton, D. A. Aquino, I. Hozumi, F. -C. Chiu, C. F. Brosnan, Quantitative aspects of reactive gliosis: a review. Neurochemical Research. ,vol. 17, pp. 877- 885 ,(1992) , 10.1007/BF00993263
Isao Hozumi, Fung-Chow Chiu, William T. Norton, Biochemical and immunocytochemical changes in glial fibrillary acidic protein after sab wounds Brain Research. ,vol. 524, pp. 64- 71 ,(1990) , 10.1016/0006-8993(90)90492-T
Y Ganat, S Soni, M Chacon, M.L Schwartz, F.M Vaccarino, Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Neuroscience. ,vol. 112, pp. 977- 991 ,(2002) , 10.1016/S0306-4522(02)00060-X
James W Fawcett, Richard.A Asher, The glial scar and central nervous system repair Brain Research Bulletin. ,vol. 49, pp. 377- 391 ,(1999) , 10.1016/S0361-9230(99)00072-6
Kouko Tatsumi, Hirohide Takebayashi, Takayuki Manabe, Kenji F. Tanaka, Manabu Makinodan, Takahira Yamauchi, Eri Makinodan, Hiroko Matsuyoshi, Hiroaki Okuda, Kazuhiro Ikenaka, Akio Wanaka, Genetic fate mapping of Olig2 progenitors in the injured adult cerebral cortex reveals preferential differentiation into astrocytes Journal of Neuroscience Research. ,vol. 86, pp. 3494- 3502 ,(2008) , 10.1002/JNR.21862