Distribution of endothelin-1 (ET) receptors (ETA and ETB) and immunoreactive ET-1 in porcine saphenous vein–carotid artery interposition grafts

摘要: Abstract Proliferation of vascular smooth muscle cells (VSMC) is a principal event in neointima formation saphenous vein–coronary artery bypass grafts. Since endothelin-1 (ET-1) promotes VSMC replication and ET-1 receptor antagonists inhibit arterial injury models, it reasonable to propose that may be involved vein However, not known what alterations its receptors (if any) occur The objective this study, therefore, was investigate the distribution subtypes (ET A ET B ) porcine Unilateral interposition grafting performed by end anastomosis after excision segment carotid Landrace pigs. One month surgery, grafts, ungrafted veins arteries were excised, immunoreactivity identified immunocytochemistry studied using autoradiography. In there greater density compared both tunica media neointima. binding than or but graft artery. Immunoreactive located endothelial throughout graft. Dense (to ETA receptors) also associated with microvessels adventitia within strong neutrophils which present high numbers at subendothelium adventitia. It concluded play role thickening medial neointimal level, whereas microangiogenesis. higher levels relative render conduit susceptible formation. These data indicate studies on effect pathobiology disease warranted.