Epidermal growth factor receptor mutations in small cell lung cancer.

摘要: Purpose: The vast majority of epidermal growth factor receptor ( EGFR ) mutations occur in lung adenocarcinoma, and even rare cases other subtypes with this mutation, such as adenosquamous cell carcinoma, are associated adenocarcinoma histology. According to adenocarcinoma-specific nature analysis small cancers (SCLC) may provide a clue its histogenesis. Experimental Design: mutational status the gene was accessed cohort 122 patients SCLC; all were from single institute. When mutated, copy number also examined. Results: detected five SCLCs (4%). mainly light smoker histologic combined subtype. All but one tumors harbored amplifications. Notably, three SCLC subtype, both components an whereas amplification only component. A partial response achieved patient (with mutation) who treated gefitinib. Conclusions: Although SCLC, subtype smokers have chance harboring mutations. For tyrosine kinase inhibitor can be treatment option. In terms molecular pathogenesis, it is suggested that some developed pre-existing adenocarcinomas mutations, development not simply linear, taking into consideration discordant distribution amplification.