Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome

摘要: Dengue represents a serious social and economic public health problem; then trying to contribute improve its control, the objective of this research was develop phytoterapics for dengue treatment using natural resources from Caatinga biome. Galactomannans isolated Adenanthera pavonina L., Caesalpinia ferrea Mart., Dimorphandra gardneriana Tull were chemically sulfated in order evaluate antioxidant, antiviral activities role inhibition virus DENV-2 Vero cells. A positive correlation between degree sulfation, antioxidant observed. The galactomannans showed binding surface, indicating that they interact with DENV-2. C. 96% replication followed by D. (94%) A. (77%) at 25 µg/mL all also activity. This work is first report effects against results are very promising suggest these plants biome act early step viral infection. Thus, may as an entry inhibitor