Serum biochemical changes associated with cystic ovarian degeneration in pigs after atrazine treatment
作者： Tihomira Gojmerac , Božica Kartal , Stipica Ćurić , Marijan Žurić , Stjepan Kušević
DOI: 10.1016/0378-4274(96)03631-4
关键词:
摘要: Biochemical and histopathological parameters of the ovarian function were observed to assess toxic effect low dose atrazine, an s-triazine herbicide, in female pigs (gilts) undergoing intensive breeding. Female (cross-bred between Swedish German landrace) received 2 mg atrazine kg−1 body wt. feed daily during 19 days oestrous cycle. The last treatment day corresponded -3 onset next expected oestrus. Blood samples collected 3 times at 3-h intervals on first 5 post-treatment days. Serum 17β-oestradiol (17β-E) progesterone (P) concentrations determined. A significantly higher (P < 0.05 P 0.001, respectively) serum concentration lower 0.01 17β-E was recorded 48 24 h before oestrus atrazine-treated pigs, as compared intact pigs. failed occur, but no other adverse clinical reactions associated with recorded. Histopathological examination ovaries treated indicated multiple follicular cysts persistence corpus luteum. findings showed that subacute exposure prolonged their
elsevier.com
sci-hub.se 参考文章(18)
R. O. Greep, Reproductive physiology, II. University Park Press.. ,(1977)
Ilkka Hemmilä, Salifu Dakubu, Veli-Matti Mukkala, Harri Siitari, Timo Lövgren, Europium as a label in time-resolved immunofluorometric assays Analytical Biochemistry. ,vol. 137, pp. 335- 343 ,(1984) , 10.1016/0003-2697(84)90095-2
D.F.M. Van De Wiel, J. Erkens, W. Koops, Elène Vos, A.A.J. Van Landeghem, Periestrous and Midluteal Time Courses of Circulating LH, FSH, Prolactin, Estradiol-17β and Progesterone in the Domestic Pig Biology of Reproduction. ,vol. 24, pp. 223- 233 ,(1981) , 10.1095/BIOLREPROD24.2.223
Kean S Goh, Don J Weaver, Jean Hsu, Sylvia J Richman, Duc Tran, Terrell A Barry, None, ELISA regulatory application: compliance monitoring of simazine and atrazine in California soils. Bulletin of Environmental Contamination and Toxicology. ,vol. 51, pp. 333- 340 ,(1993) , 10.1007/BF00201749
I. J. SHEARER, K. PURVIS, G. JENKIN, N. B. HAYNES, Peripheral plasma progesterone and oestradiol-17 levels before and after puberty in gilts. Reproduction. ,vol. 30, pp. 347- 360 ,(1972) , 10.1530/JRF.0.0300347
Ẑ. Teẑak, B. Šimić, J. Kniewald, Effect of pesticides on oestradiol-receptor complex formation in rat uterus cytosol. Food and Chemical Toxicology. ,vol. 30, pp. 879- 885 ,(1992) , 10.1016/0278-6915(92)90054-O
Branimir Šimić, Jasna Kniewald, Zlatko Kniewald, Effects of atrazine on reproductive performance in the rat Journal of Applied Toxicology. ,vol. 14, pp. 401- 404 ,(1994) , 10.1002/JAT.2550140603
Timo Lövgren, Ilkka Hemmilä, Kim Pettersson, Jarkko U. Eskola, Eric Bertoft, Determination of hormones by time-resolved fluoroimmunoassay Talanta. ,vol. 31, pp. 909- 916 ,(1984) , 10.1016/0039-9140(84)80220-9
Tihomira Babić-Gojmerac, Zlatko Kniewald, Jasna Kniewald, Testosterone metabolism in neuroendocrine organs in male rats under atrazine and deethylatrazine influence Journal of Steroid Biochemistry. ,vol. 33, pp. 141- 146 ,(1989) , 10.1016/0022-4731(89)90369-5
Thomas S. Foster, Shahamat U. Khan, M. Humayoun Akhtar, Metabolism of atrazine by the soluble fraction (105000g) from chicken liver homogenates. Journal of Agricultural and Food Chemistry. ,vol. 27, pp. 300- 302 ,(1979) , 10.1021/JF60222A003