Lack of Penicillin Resensitization in Patients With a History of Penicillin Allergy After Receiving Repeated Penicillin Courses

摘要: Background Up to 10% of the population reports an allergy penicillin, yet more than 80% these individuals lack penicillin-specific IgE antibodies. A negative result on a penicillin skin test is highly accurate in identifying who can safely receive antibiotic at time testing. However, its predictive value for future courses unknown because it uncertain whether patients with history are risk becoming resensitized. Objective To determine rate resensitization adult after they challenged repeated oral penicillin. Methods Adult consistent IgE-mediated mechanism were recruited and underwent Those results 3 successive 10-day V potassium (250 mg by mouth times day), providing their remained prior each course. Patients positive not challenged. Results Of 53 initially results, 46 completed protocol, tolerated all throughout. No had converted from positive, yielding 0% (upper 95% confidence interval, 2.1%). Conclusions increased receiving Because subsequent administrations beyond testing, be tested electively, which may avoid unnecessary treatment alternate broad-spectrum antibiotics.