Indole-pyruvic acid treatment reduces damage in striatum but not in hippocampus after transient forebrain ischemia in the rat

摘要: Abstract The effects of treatment with indole-pyruvic acid, an endogenous metabolite tryptophan converted into kynurenic acid in the brain, were studied rats after transient forebrain ischemia induced by 4-vessel occlusion procedure. histological analysis showed a significant protective effect on striatal ischemic lesions assessed extent regional atrophy and area neuronal disappearance 14 days ischemia. Striatal neurons labelled dopamine adenosine 3′:5′ monophosphate regulated phosphoprotein-32 immunoreactivity. Conversely, increased loss, glial fibrillary acidic protein immunoreactivity, index post-injury astroglial activation, observed hippocampal formation, especially CA3 field, indole pyruvic acid-treated when compared vehicle-treated rats. did not produce any improving test assessing short-term impairments (motor score at 24 h 48 post-ischemia). Furthermore, no found performance water T-maze 7 post-ischemia. opposite lesion different brain regions may be related to its multiple neurochemical actions brain. damage striatum due conversion broad spectrum glutamate receptor antagonist. At level, where antagonists have been proved ineffective present model, acid-induced changes monoamine availability lead worsening damage.