Individual human phenotypes in metabolic space and time.

摘要: Differences between individual phenotypes are due both to differences in genotype and exposure different environmental factors. A fundamental contribution the definition of phenotype for clinical therapeutic applications would come from a deeper understanding metabolic phenotype. The existence unique has been hypothesized, but experimental evidence only recently collected. Analysis over timescale years shows that largely invariant. present work also supports idea can be considered metagenomic entity is strongly affected by gut microbiome host phenotype, latter defined genetic contributions.