The genetics of bone marrow transplantation in the rat.

摘要: We have used a variety of standard inbred, recombinant, and congenic rat strains to establish the effect MHC non-MHC genetic incompatibilities on bone marrow transplantation. The role these loci in successful establishment engraftment was first determined by examining potential do-nor protect recipient rats from lethal dose myeloablative drug busulfan. Similar donor/recipient combinations were then examine effects same induction fatal graft-versus-host disease (GVHD) recipients conditioned with combination busulfan cyclophosphamide. data obtained indicate that: (1) difference for entire is sufficient prevent produce GVHD; (2) class I RT1.A locus has differential transplantation, since disparity this prevents engraftment, while gene little development (3) RT1.E no does not stimulate (4) II locus, RT1.D, can elicit (5) incompatibility genes GVHD.