Epidemiology of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) among a cohort of HIV-infected and uninfected Ghanaian women

摘要: There is limited data in Ghana on the epidemiology of HPV and cervical neoplasia their associations with HIV. This study aimed to compare among HIV-1 seropositive HIV-seronegative Ghanaian women: (1) prevalence, genotype distribution risk factors associated infection; (2) prevalence abnormal cytology. A comparative frequency-matched was conducted a systematic sample women aged ≥18 years attending HIV general outpatient clinics Cape Coast Teaching Hospital, Ghana. Participants were interviewed samples collected for genotyping (Seegene Anyplex-II HPV28) cytological testing. Overall, 333 recruited, 163 170 mean age 43.8 years (SD ±9.4)) 44.3 years ±12.8), respectively. The 14 high-risk (hr) genotypes higher (65.6% vs. 30.2%, P < 0.0001), as proportion multiple hr.-HPV infections (60.6% 21.3%, P < 0.0001). HPV35 most prevalent both groups (11.9% 5.3%). main infection HIV-positive circumcision status sexual partner HIV-negative positive women. Abnormal cytology (any SIL: 14.1% 1.2%, P < 0.0001; low-grade SIL [LSIL]: 4.9% 0.6%, P = 0.02; high-grade 1.8% 0%, P = 0.07). Among women, number pregnancies CD4+ cell count LSIL+ strong association between abnormalities (aOR = 4.7, 95%CI: 1.3–17.7, P = 0.02). infected bear significant burden related disease. Prevention screening programmes should be specifically deployed this population