Does neuropsychological performance in OCD relate to different symptoms? A meta‐analysis comparing the symmetry and obsessing dimensions

摘要: Background Investigations of neuropsychological functioning in obsessive-compulsive disorder (OCD) have produced mixed results for deficits executive (EF), attention, and memory. One potential explanation varied findings may relate to the heterogeneity symptom presentations, different clinical or neurobiological characteristics underlie these symptoms. Methods We investigated differences between two symptoms groups, obsessing/checking (O/C) symmetry/ordering (S/O), based on data suggesting an association with motivations: harm avoidance incompleteness, respectively. Ten studies (with 628 patients) were included each investigation assessed at least one 14 domains. Results The S/O domain demonstrated small, negative correlations overall functioning, performance EF, memory, visuospatial ability, cognitive flexibility, verbal working O/C memory performance. A comparison groups identified large effect sizes showing that dimension was more strongly related poorer overall, domains subdomain Conclusions Findings support existing evidence OCD symptoms, their associated core motivations, unique patterns and, potentially dysfunction neural circuits.