作者: Menachem Rubinstein , Efrat Dvash
DOI: 10.1097/MNH.0000000000000381
关键词:
摘要: Purpose of review This will critically highlight the role leukotrienes as mediators renal diseases and drug nephrotoxicity. It also discuss recently identified mechanism cysteinyl induction action, propose clinical implementation these findings. Recent findings Since last reviewed in 1994, were shown to mediate drug-associated nephrotoxicity, transplant rejection morbidity several models diseases. Although may be released by various infiltrating leukocytes, a recent study demonstrated that cytotoxic agents trigger production leukotriene C4 (LTC4) mouse kidney cells activating biosynthetic pathway based on microsomal glutathione-S-transferase 2 (MGST2). LTC4 then elicits nuclear accumulation hydrogen peroxide-generating NADPH oxidase 4, leading oxidative DNA damage cell death. inhibitors, commonly used systemic asthma drugs, alleviated proximal tubular attenuated morbidity. Summary Cysteinyl mast symptoms asthma, including bronchoconstriction vasoconstriction. Therefore, effective inhibitors approved orally administered drugs. The cytotoxicity nephrotoxic are involved numerous diseases, suggest such drugs ameliorate drug-induced well some