Synthesis and characterization of poly(2-methacryloyloxyethyl phosphorylcholine) onto graphene oxide
作者： Suxing Jin , Ninglin Zhou , Dong Xu , Jian Shen
DOI: 10.1002/PAT.3148
关键词:
摘要: The polyzwitterionic brushes comprised of poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) segments, which are used for surface modification polymers and biocompatible coatings, were investigated. In this work, reverse surface-initiated atom transfer radical polymerization (RATRP) zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) is employed to tailor the functionality graphene oxide (GeneO) in a well-controlled manner produce series well-defined hemocompatible hybrids (termed as GeneO-g-pMPC). complexes characterized by FT-IR, XRD, Raman. Results show that MPC has been coordinated on sheet. Thermal stability nanocomposites comparison with neat copolymer revealed thermogravimetric analysis differential thermal analysis. Scanning electron microscopy transmission microscope images nanoconposite displays pMPC chains capable existing GeneO sheet RATRP. biocompatibility properties measured plasma recalcification profile tests, hemolysis test, MTT assays, respectively. results confirm grafting can substantially enhance hemocompatibility particles, GeneO-g-pMPC be biomaterials without causing any hemolysis. With versatility RATRP excellent polymer chains, nanoparticles desirable blood readily tailored cater various biomedical applications. Copyright © 2013 John Wiley & Sons, Ltd.
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