Suicidality associated with antiepileptic drugs: implications for the treatment of neuropathic pain and fibromyalgia.

摘要: Anti-epileptic drugs (AEDs) have a prominent role in the treatment of several types chronic pain. Gabapentin and pregabalin are recommended as first-line treatments for various neuropathic pain conditions, carbamazepine oxcarbazepine commonly used trigeminal neuralgia, certain AEDs considered second- or third-line [3,7,11,12,25]. In addition, is fibromyalgia [8], topiramate valproic acid migraine prophylaxis [13,33]. Given played by treatment, it important to consider recent research recommendations regarding suicidality, which includes both suicidal behavior ideation [17,31,37]. On basis meta-analysis, U.S. Food Drug Administration (FDA) concluded that AED any indication associated with an increased risk suicidality [37]; consequence, product information was changed include warnings about this risk. After conducting independent review, European Medicines Agency (EMA) also instituted [22,27]. In evaluating AEDs, consideration conditions they prescribed suicide risk, including epilepsy [10,20] psychiatric disorders [6,14,21]. Chronic [32,34,36], many 50% patients comorbid depression [5], well-established factor [9]. The objective article review on discuss its implications fibromyalgia. The prophylactic rather than symptomatic, beyond scope seizure their mood stabilizing effects.