Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging.

摘要: Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play fundamental role elucidating several aspects biology. Within magnetic resonance (MRI) modality, chemical exchange saturation transfer (CEST) approach has emerged as new technique that provides high spatial resolution and sensitivity for acidosis. This mini-review describes CEST-based methods to non-invasively investigate important involved, such glucose lactate, well measurement Approaches have been exploited assess response anticancer therapies will also be reported each specific technique.