Scatter factor/hepatocyte growth factor gene transfer increases rat blood–glioma barrier permeability
作者： Adam A Book , Srikanth Ranganathan , Roger Abounader , Eliot Rosen , John Laterra
DOI: 10.1016/S0006-8993(99)01527-9
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摘要: Abstract Malignant gliomas are associated with a dysfunctional blood–tumor barrier (BTB) that causes substantial morbidity. Scatter factor/hepatocyte growth factor (SF/HGF) is multifunctional correlates glioma malignancy and has several biological properties suggest role in enhancing blood–glioma permeability. In this study, we examined the effects of cell SF/HGF expression on BTB permeability to horseradish peroxidase (HRP). Fischer 344 rats bearing intrastriatal 9L tumors engineered secrete (9L-SF) SF/HGF-negative control (9L-neo) received intracardiac injections HRP were rapidly decapitated. Densitometric analysis brain sections reacted diaminobenzidine showed significantly greater extravascular surrounding SF/HGF-secreting than 9L-neo comparable size (p
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sci-hub.se 参考文章(58)
C. Guerin, J. Laterra, Regulation of angiogenesis in malignant gliomas EXS. ,vol. 79, pp. 47- 64 ,(1997) , 10.1007/978-3-0348-9006-9_4
J Jääskeläinen, M Haltia, K Alitalo, E Hatva, A Paetau, A Kaipainen, P Mentula, Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. American Journal of Pathology. ,vol. 146, pp. 368- 378 ,(1995)
E Klineberg, S Koochekpour, G Taylor, M Jeffers, E A Hudson, G F Vande Woude, J H Resau, S Rulong, Met and Hepatocyte Growth Factor/Scatter Factor Expression in Human Gliomas Cancer Research. ,vol. 57, pp. 5391- 5398 ,(1997)
G. Breier, B. Millauer, A. Ullrich, W. Risau, K. H. Plate, Up-Regulation of Vascular Endothelial Growth Factor and Its Cognate Receptors in a Rat Glioma Model of Tumor Angiogenesis Cancer Research. ,vol. 53, pp. 5822- 5827 ,(1993)
G E Palade, W G Roberts, Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Research. ,vol. 57, pp. 765- 772 ,(1997)
R. Forough, Z. Xi, M. MacPhee, S. Friedman, K.A. Engleka, T. Sayers, R.H. Wiltrout, T. Maciag, Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1. Journal of Biological Chemistry. ,vol. 268, pp. 2960- 2968 ,(1993) , 10.1016/S0021-9258(18)53867-9
Tumor Angiogenesis: A Quantitative Method for Histologic Grading Journal of the National Cancer Institute. ,vol. 48, pp. 347- 356 ,(1972) , 10.1093/JNCI/48.2.347
R. O. WELLER, M. FOY, SUSAN COX, THE DEVELOPMENT AND ULTRASTRUCTURE OF THE MICROVASCULATURE IN MALIGNANT GLIOMAS Neuropathology and Applied Neurobiology. ,vol. 3, pp. 307- 322 ,(1977) , 10.1111/J.1365-2990.1977.TB00593.X
C.L. Farrell, C.R. Farrell, P.A. Stewart, R.F. Del Maestro, C.G. Ellis, The Functional Microcirculation in a Glioma Model International Journal of Radiation Biology. ,vol. 60, pp. 131- 137 ,(1991) , 10.1080/09553009114551711
Gregory R. Criscuolo, Marsha J. Merrill, Edward H. Oldfield, Further characterization of malignant glioma-derived vascular permeability factor Journal of Neurosurgery. ,vol. 69, pp. 254- 262 ,(1988) , 10.3171/JNS.1988.69.2.0254