Diabetes and cancer: A critical appraisal of the pathogenetic and therapeutic links.

摘要: Diabetes and cancer represent two common, multifactorial, chronic potentially fatal diseases, not infrequently co-diagnosed in the same patient. Epidemiological data demonstrate significant increases of incidence patients with obesity diabetes, which is more evident for certain site-specific cancers. Although there increasing evidence that strongly indicates an augmented risk diabetic patients, several confounding factors complicate ability to precisely assess risk. Mainly insulin-resistant states (such as type 2 diabetes mellitus metabolic syndrome), direct associations between obesity-related hyperinsulinemia circulating insulin-like growth factor-1 (IGF-1) levels have been implicated key mechanisms involved carcinogenesis. Whilst anti-diabetic drugs can increase risk, anti-proliferative may cause or aggravate pre-existing diabetes. Additionally, number targeted anti-cancer therapies interfere pathways shared by IGF-1 insulin receptors, showing a adverse effect on glucose metabolism through various mechanisms. requirement large-scale randomized evidence, present review summarizes majority epidemiological association studies types cancer, discussing pathophysiological be promoting carcinogenesis potential impact different