(S)‐Ibuprofen‐imprinted polymers incorporating γ‐methacryloxypropyl‐trimethoxysilane for CEC separation of ibuprofen enantiomers
作者： Qi-Liang Deng , Zhi-Hong Lun , Ru-Yu Gao , Li-Hua Zhang , Wei-Bing Zhang
关键词:
摘要: In this report, a novel preparation method of molecularly imprinted polymers (MIPs) for CEC was developed. Molecularly monolithic columns (S)-ibuprofen were prepared and evaluated, in which charged entities responsible establishing EOF have been derived from gamma-methacryloxypropyltrimethoxysilane (gamma-MAPS), hydrolyzed following copolymerization with 4-vinylpyridine (4-VPY) ethylene glycol dimethacrylate (EDMA). The molecular recognition the stationary phase investigated aqueous nonaqueous media, respectively. experimental results indicated that material showed reasonably stable separation materials capable separating racemic ibuprofen, task could not be accomplished by MIPs parallel, using methacrylic acid (MAA) as functional monomer. efficiency at pH 3.2 first-eluted enantiomer last-eluted (the analyte) 128 700 2100 plates/m,
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