Possibility of cross-species/subtype reassortments in influenza A viruses: an analysis of nonstructural protein variations.

摘要: The reassortment of genetic segments from different host species and subtypes influenza A viruses occurs frequently, which may generate new strains causing flu epidemic or pandemic. However, the underlined mechanisms were less addressed viewpoint protein variations. Recently, we used amino-acid pair predictability as an indicator to convert eight types virus proteins into predictable portion pairs, then applied models I II ANOVA estimate their differences in terms species. In order get a full picture, 2729 1063 non-structural 1 2 analyzed this study. results are consistent with those obtained hemagglutinin, neuraminidase, nucleoprotein, polymerase acidic protein, basic 2, matrix indicating that inter-species/subtypes variations smaller than intra-species/subtype ones. Our findings provide statistical evidence can partially explains why cross-subtype mutation cross-species infection easily occur during co-infecting strains.