Prospects for mTOR-mediated functional repair after central nervous system trauma.
作者： Martin Berry , Zubair Ahmed , Peter Morgan-Warren , Daniel Fulton , Ann Logan
DOI: 10.1016/J.NBD.2015.10.002
关键词:
摘要: Recent research has suggested that the growth of central nervous system (CNS) axons during development is mediated through PI3K/Akt/mammalian target rapamycin (mTOR) intracellular signalling axis and suppression activity in this pathway occurs maturity as levels phosphatase tensin homologue (PTEN) rise inhibit PI3K activation mTOR, accounting for failure axon regeneration injured adult CNS. This hypothesis supported by findings confirming PTEN experimental animals promotes impressive visual corticospinal motor systems. review focuses on these recent developments, discussing therapeutic potential a mTOR-based treatment aimed at promoting functional recovery CNS trauma patients, recognising to fulfil ambition, new therapy should aim promote not only but also remyelination regenerated axons, neuronal survival re-innervation denervated targets accurate axonal guidance synaptogenesis, all with minimal adverse effects. The translational challenges presented implementation axogenic are discussed.
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