Protection effects of Taurine supplementation against cisplatin-induced nephrotoxicity in rats.
作者： Sherif Y. Saad , Ammar C. Al-Rikabi
DOI: 10.1159/000048587
关键词:
摘要: Backgound: Taurine, which is the major intracellular free β-amino acid, known to be an antioxidant and a membrane-stabilizing agent. This study was designed investigate protective role of taurine supplementation against cisplatin-induced nephrotoxicity. Methods: Male Wistar rats were divided into six groups treated as follows: (1) saline-treated control drinking tap water, (2) plus taurine-supplemented (1.5% in water), (3) taurine-depleted (3% β-alanine (4) cisplatin-treated, CDDP 6 mg/kg intraperitoneally, (5) CDDP-treated (6) CDDP-treated. Rats sacrificed 7 days after treatment, serum well kidneys isolated analyzed. Results: showed increased kidney weight percentage total body weight, creatinine BUN levels decreased albumin calcium levels. Also, treatment resulted depletion GSH content, reduction glutathione peroxidase (GSH-Px) activity MDA production level. Taurine attenuated CDDP-induced nephrotoxicity manifested by jeopardizing elevation Moreover, restored content GSH-Px reduced platinum accumulation tissue following treatment. Histopathological examination revealed tubular atrophy, necrosis desquamation renal cells. However, protected histopathological changes. Conclusions: The data suggest that effectively attenuates within counteracts deleterious effect on function.
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